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Abstract Rett syndrome (RTT), caused by mutations in the methyl-CpG protein 2 gene link (MeCP2) is a developmental disorder autism spectrum that is degenerative, affecting mostly women. MeCP2 mutant mice have reduced levels of brain-derived (BDNF) in the brain neurotrophic factor, conditional deletion and overexpression of BDNF in the brain accelerates and decelerates, respectively, progression pine of the disease in MeCP2 mutant pine mice.
Thus, we tested the hypothesis that the 7,8-Dihydroxyflavone pine (7,8-DHF), a small molecule known to activate the receptor of high affinity BDNF (TrkB) in the CNS, lessen the progression pine of disease in MeCP2 mutant mice.
After weaning, 7,8-DHF was administered in drinking water for a lifetime. Mutant treated mice lived much longer compared to other mutant mice scope untreated (80 4 and 66 2 days, respectively). 7,8-DHF retards weight loss, increasing the size of the nuclei of neurons and improves voluntary motor (running wheel) away in MeCP2 mutant mice.
Thus, although the specific mechanisms are not fully known, pine 7,8-DHF appears to reduce symptoms in MeCP2 mutant mice and may have potential as a therapeutic treatment pine for RTT patients.
Pathophysiology of Epilepsy in Autism Spectrum Disorders pine
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